反应详情

温度

0 °C

Dissolve (S)-3-(1H-Indol-3-ylmethyl)-1-(2-phenyl-ethyl)-2-oxo-piperazine (0.545 g, 1.64 mmol) in dichloromethane (20 mL). Cool to 0° C. Pass hydrochloride gas through the solution for 15 minutes. Evaporate in vacuo to obtain a residue. Triturate with diethyl ether to give a solid. Filter and dry in vacuo to give the title compound. Elem. Anal. calculated for C21H23N3O.HCl.0.8 H2O: C, 65.74; H, 6.70; N, 10.95. Found: C, 66.14; H, 6.96; N, 10.57. Specific rotation [α]2D0 =-104° (c=1.00, DMSO).

1. customEvaporate in vacuo
2. customto obtain a residue
3. customTriturate with diethyl ether
4. customto give a solid
5. filtrationFilter
6. customdry in vacuo