O-Xylene → HCID 54304088, compound

HRID 344253Notes

Reaction equation

HRID 344253 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7](Cl)=[O:8].[CH3:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=1[CH3:17].[Cl-].[Al+3].[Cl-].[Cl-]>O>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:13]1[CH:14]=[CH:15][C:16]([CH3:17])=[C:11]([CH3:10])[CH:12]=1)=[O:8]

Participants

5

Reactant 3

HCID 7237O-XyleneHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 54304088HCID 54304088, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6-Bromohexanoyl chloride (2.0 g) was added to o-xylene (20 ml), and aluminum chloride (1.4 g) was added at -20° C., which was followed by stirring for 30 min. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and the solvent was evaporated under reduced pressure to give 2.6 g of 6-bromo-1-(3,4-dimethylphenyl)-1-hexanone.

Workup

  1. additionwas added at -20° C.
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6cb9f1b402524b038ee926006323fd29
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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