Anisole → 1-Hexanone, 6-bromo-1-(4-methoxyphenyl)-

HRID 344254Notes

Reaction equation

HRID 344254 reaction equation
[C:1]1([O:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](Cl)=[O:16].[Cl-].[Al+3].[Cl-].[Cl-]>>[Br:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([C:4]1[CH:5]=[CH:6][C:1]([O:7][CH3:8])=[CH:2][CH:3]=1)=[O:16]

Participants

4

Reactant 3

HCID 7519AnisoleHCID 898486-Bromohexanoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 106131051-Hexanone, 6-bromo-1-(4-methoxyphenyl)-Yield 100.4%

Procedure

Anisole (1.16 g), 6-bromohexanoyl chloride (2.3 g) and aluminum chloride (1.5 g) were reacted and treated in the same manner as in Preparation Example 105 to give 3.07 g of 6-bromo-1-(4-methoxyphenyl)-1-hexanone.

Workup

  1. additiontreated in the same manner as in Preparation Example 105

Sources & evidence

ORD record
ord-6e534fe8323d43fd830d792fac773f68
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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