Potassium Carbonate → HCID 70074942, compound

HRID 344285Notes

Reaction equation

HRID 344285 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:16]1[CH2:24][O:23][CH:19]([CH2:20][CH2:21]Cl)[CH:18]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)[O:17]1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:16]1[CH2:24][O:23][CH:19]([CH2:20][CH2:21][N:13]2[CH2:12][CH2:11][CH:10]([CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:15][CH2:14]2)[CH:18]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)[O:17]1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamateHCID 70074626HCID 70074626, compound

Product 1

HCID 70074942HCID 70074942, compoundYield 37.7%

Procedure

4-(tert-Butoxycarbonylaminomethyl)piperidine (10.0 g) as a starting compound, 4-ethylenedioxy-4-(4-methoxyphenyl)butyl chloride (12.0 g) and potassium carbonate (19.3 g) were reacted and treated in the same manner as in Preparation Example 181 to give 7.65 g of 1-(4-ethylenedioxy-4-(4-methoxyphenyl)butyl)-4-(tert-butoxycarbonylaminomethyl)piperidine.

Workup

  1. additiontreated in the same manner as in Preparation Example 181

Sources & evidence

ORD record
ord-889b7fe02ea8447da5f95f61bfc79ede
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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