2-Thiophenecarbonyl chloride → HCID 54211601, compound

HRID 344310Notes

Reaction equation

HRID 344310 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24](Cl)=[O:25].[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31](C(O)=O)=[C:30]([O:38][CH3:39])[CH:29]=1>>[NH2:27][C:28]1[C:36]([Cl:37])=[CH:35][C:31]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:24]([C:20]3[S:19][CH:23]=[CH:22][CH:21]=3)=[O:25])[CH2:11]2)=[O:7])=[C:30]([O:38][CH3:39])[CH:29]=1

Participants

4

Reactant 3

HCID 789282-Thiophenecarbonyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 54211601HCID 54211601, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.05 g) as starting compound was reacted and treated in the same manner as in Example 1 using 2-thiophenecarbonyl chloride (0.48 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.82 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(2-thiophenecarbonylamino)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-7399f61fe4c241488f99a01b1a94d1ab
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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