Phenylacetyl chloride → HCID 54309550, compound

HRID 344315Notes

Reaction equation

HRID 344315 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[C:20]1([CH2:26][C:27](Cl)=[O:28])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:27](=[O:28])[CH2:26][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

4

Reactant 3

HCID 7679Phenylacetyl chlorideHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780050HCID 53780050, compound

Product 1

HCID 54309550HCID 54309550, compound

Procedure

4-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (1.00 g) as starting compound was reacted and treated in the same manner as in Example 1 using phenylacetyl chloride (0.50 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.54 g) to give 4-amino-5-chloro-2-methoxy-N-((3R)-1-(4-phenylacetylaminobutyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-badce00865e2477ea8a4aea27bedefa5
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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