Methyl Isocyanate → HCID 54480720, compound

HRID 344321Notes

Reaction equation

HRID 344321 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[CH3:21][N:22]=[C:23]=[O:24].[NH2:25][C:26]1[C:34]([Cl:35])=[CH:33][C:29](C(O)=O)=[C:28]([O:36][CH3:37])[CH:27]=1>>[NH2:25][C:26]1[C:34]([Cl:35])=[CH:33][C:29]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:23]([NH:22][CH3:21])=[O:24])[CH2:11]2)=[O:7])=[C:28]([O:36][CH3:37])[CH:27]=1

Participants

4

Reactant 3

HCID 12228Methyl IsocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808196HCID 53808196, compound

Product 1

HCID 54480720HCID 54480720, compound

Procedure

5-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (0.84 g) as starting compound was reacted and treated in the same manner as in Example 34 using methyl isocyanate (0.26 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.58 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(5-(3-methylureido)pentyl)pyrrolidin-3-ylmethyl)-benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-4e3ffccb41a24f9488e8a39d932a58c5
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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