Propyl isocyanate → HCID 53757672, compound

HRID 344327Notes

Reaction equation

HRID 344327 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11]1)=[O:7])(C)(C)C.[CH2:20]([N:23]=[C:24]=[O:25])[CH2:21][CH3:22].[NH2:26][C:27]1[C:35]([Cl:36])=[CH:34][C:30](C(O)=O)=[C:29]([O:37][CH3:38])[CH:28]=1>>[NH2:26][C:27]1[C:35]([Cl:36])=[CH:34][C:30]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:24]([NH:23][CH2:20][CH2:21][CH3:22])=[O:25])[CH2:11]2)=[O:7])=[C:29]([O:37][CH3:38])[CH:28]=1

Participants

4

Reactant 3

HCID 61033Propyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53780050HCID 53780050, compound

Product 1

HCID 53757672HCID 53757672, compound

Procedure

4-((3R)-3 -tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)butylamine (2.00 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-propyl isocyanate (0.76 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (1.49 g) to give 4-amino-5-chloro-2-methoxy-N-((3R)-1-(4-(3-n-propylureido)butyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-8e2c8cb9ab994fe2a5345378b47b74e4
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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