Butyl isocyanate → HCID 54298237, compound

HRID 344334Notes

Reaction equation

HRID 344334 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[CH2:21]([N:25]=[C:26]=[O:27])[CH2:22][CH2:23][CH3:24].[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:26]([NH:25][CH2:21][CH2:22][CH2:23][CH3:24])=[O:27])[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

4

Reactant 3

HCID 8110Butyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808195HCID 53808195, compound

Product 1

HCID 54298237HCID 54298237, compound

Procedure

5-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)pentylamine (2.00 g) as starting compound was reacted and treated in the same manner as in Example 34 using n-butyl isocyanate (0.79 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.54 g) to give 4-amino-N-((3R)-1-(5-(3-n-butylureido)pentyl)pyrrolidin-3-ylmethyl)-5-chloro-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-55acc288529543ceafabbf274dd3b3f9
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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