Phenyl isocyanate → HCID 57091115, compound

HRID 344339Notes

Reaction equation

HRID 344339 reaction equation
C(O[C:6]([NH:8][CH2:9][C@@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH2:20])[CH2:11]1)=[O:7])(C)(C)C.[C:21]1([N:27]=[C:28]=[O:29])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34](C(O)=O)=[C:33]([O:41][CH3:42])[CH:32]=1>>[NH2:30][C:31]1[C:39]([Cl:40])=[CH:38][C:34]([C:6]([NH:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:28]([NH:27][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:29])[CH2:11]2)=[O:7])=[C:33]([O:41][CH3:42])[CH:32]=1

Participants

4

Reactant 3

HCID 7672Phenyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53808197HCID 53808197, compound

Product 1

HCID 57091115HCID 57091115, compound

Procedure

5-((3S)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)-pentylamine (1.52 g) as starting compound was reacted and treated in the same manner as in Example 34 using phenyl isocyanate (0.58 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.75 g) to give 4-amino-5-chloro-2-methoxy-N-((3S)-1-(5-(3-phenylureido)pentyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-539bea569ba74e8f9752eb75b5168596
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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