Phenyl isocyanate → HCID 22941690, compound

HRID 344342Notes

Reaction equation

HRID 344342 reaction equation
C(O[C:6]([NH:8][CH2:9][C@H:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:11]1)=[O:7])(C)(C)C.[C:22]1([N:28]=[C:29]=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35](C(O)=O)=[C:34]([O:42][CH3:43])[CH:33]=1>>[NH2:31][C:32]1[C:40]([Cl:41])=[CH:39][C:35]([C:6]([NH:8][CH2:9][C@H:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][C:29]([NH:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:30])[CH2:11]2)=[O:7])=[C:34]([O:42][CH3:43])[CH:33]=1

Participants

4

Reactant 3

HCID 7672Phenyl isocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53706156HCID 53706156, compound

Product 1

HCID 22941690HCID 22941690, compound

Procedure

6-((3R)-3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)-hexylamine (1.50 g) as starting compound was reacted and treated in the same manner as in Example 34 using phenyl isocyanate (0.57 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (1.01 g) to give 4-amino-5-chloro-2-methoxy-N-((3R)-1-(6-(3-phenylureido)hexyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-bce4decd4e964b668d4865c70c8eff86
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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