Methyl isothiocyanate → HCID 53695300, compound

HRID 344344Notes

Reaction equation

HRID 344344 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH2:17])[CH2:11]1)=[O:7])(C)(C)C.[CH3:18][N:19]=[C:20]=[S:21].[NH2:22][C:23]1[C:31]([Cl:32])=[CH:30][C:26](C(O)=O)=[C:25]([O:33][CH3:34])[CH:24]=1>>[NH2:22][C:23]1[C:31]([Cl:32])=[CH:30][C:26]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:17][C:20]([NH:19][CH3:18])=[S:21])[CH2:11]2)=[O:7])=[C:25]([O:33][CH3:34])[CH:24]=1

Participants

4

Reactant 3

HCID 11167Methyl isothiocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53652257tert-Butyl ((1-(2-aminoethyl)pyrrolidin-3-yl)methyl)carbamate

Product 1

HCID 53695300HCID 53695300, compound

Procedure

2-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)ethylamine (1 g) as starting compound was reacted and treated in the same manner as in Example 34 using methyl isothiocyanate (0.25 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.83 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(2-(3-methylthioureido)ethyl)pyrrolidin-3-ylmethyl)-benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-49e19d9e904946e1bd807275ec56a9aa
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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