Methyl isothiocyanate → HCID 54217784, compound

HRID 344345Notes

Reaction equation

HRID 344345 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11]1)=[O:7])(C)(C)C.[CH3:19][N:20]=[C:21]=[S:22].[NH2:23][C:24]1[C:32]([Cl:33])=[CH:31][C:27](C(O)=O)=[C:26]([O:34][CH3:35])[CH:25]=1>>[NH2:23][C:24]1[C:32]([Cl:33])=[CH:31][C:27]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:21]([NH:20][CH3:19])=[S:22])[CH2:11]2)=[O:7])=[C:26]([O:34][CH3:35])[CH:25]=1

Participants

4

Reactant 3

HCID 11167Methyl isothiocyanateHCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 53696622HCID 53696622, compound

Product 1

HCID 54217784HCID 54217784, compound

Procedure

3-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)propylamine (1.06 g) as starting compound was reacted and treated in the same manner as in Example 34 using methyl isothiocyanate (0.32 ml) and 4-amino-5-chloro-2-methoxybenzoic acid (0.91 g) to give 4-amino-5-chloro-2-methoxy-N-(1-(3-(3-methylthioureido)propyl)pyrrolidin-3-ylmethyl)benzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-281b2ba73a2445218bfb9b16f1f0bd1b
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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