4-Amino-5-chloro-2-methoxybenzoic acid → HCID 53649457, compound

HRID 344349Notes

Reaction equation

HRID 344349 reaction equation
C(O[C:6]([NH:8][CH2:9][CH:10]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]2[C:25](=[O:26])[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[O:27])[CH2:11]1)=[O:7])(C)(C)C.[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32](C(O)=O)=[C:31]([O:39][CH3:40])[CH:30]=1>>[NH2:28][C:29]1[C:37]([Cl:38])=[CH:36][C:32]([C:6]([NH:8][CH2:9][CH:10]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][N:17]3[C:18](=[O:27])[C:19]4[C:24](=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:25]3=[O:26])[CH2:11]2)=[O:7])=[C:31]([O:39][CH3:40])[CH:30]=1

Participants

3

Reactant 2

HCID 816264-Amino-5-chloro-2-methoxybenzoic acidHCID 54546395HCID 54546395, compound

Product 1

HCID 53649457HCID 53649457, compound

Procedure

2-(2-(3-tert-Butoxycarbonylaminomethylpyrrolidin-1-yl)ethyl)-2,3-dihydro-1 H-isoindole-1,3-dione (1.5 g) as starting compound was reacted and treated in the same manner as in Example 67 using 4-amino-5-chloro-2-methoxybenzoic acid (0.81 g) to give 4-amino-5-chloro-N-(1-(2-(-2,3-dihydro-1 ,3-dioxo-1 H-isoindol-2-yl)ethyl)pyrrolidin-3-ylmethyl)-2-methoxybenzamide.

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-d46fc9663eaf4f309ba550f754060637
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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