4-Pyridinecarboxaldehyde → HCID 54467680, compound

HRID 344400Notes

Reaction equation

HRID 344400 reaction equation
[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1.[N:27]1[CH:32]=[CH:31][C:30]([CH:33]=O)=[CH:29][CH:28]=1>>[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][CH2:33][C:30]3[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 540083634-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 54467680HCID 54467680, compoundYield 30.7%

Procedure

4-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (3 g) as starting compound and 4-pyridinecarboxaldehyde (0.84 g) were reacted and treated in the same manner as in Example 121 to give 1.14 g of 4-amino-5-chloro-2-methoxy-N-((1-(5-(4-pyridylmethylamino)pentyl)piperidin-4-yl)methyl)benzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 121

Sources & evidence

ORD record
ord-11f103d821cb4ceca5bd704a326b4afe
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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