3,4-Dichlorobenzaldehyde → 4-amino-5-chloro-N-((1-(3-(3,4-dichlorobenzylamino)propyl)piperidin-4-yl)methyl)-2-methoxybenzamide

HRID 344404Notes

Reaction equation

HRID 344404 reaction equation
[NH2:1][C:2]1[C:21]([Cl:22])=[CH:20][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][NH2:19])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:23][CH3:24])[CH:3]=1.[Cl:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH:29]=O>>[NH2:1][C:2]1[C:21]([Cl:22])=[CH:20][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][NH:19][CH2:29][C:28]3[CH:31]=[CH:32][C:33]([Cl:34])=[C:26]([Cl:25])[CH:27]=3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:23][CH3:24])[CH:3]=1

Participants

3

Reactant 2

HCID 227103,4-DichlorobenzaldehydeHCID 538956644-Amino-N-(1-(3-aminopropyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 541265184-amino-5-chloro-N-((1-(3-(3,4-dichlorobenzylamino)propyl)piperidin-4-yl)methyl)-2-methoxybenzamideYield 93.2%

Procedure

4-Amino-N-(1-(3-aminopropyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (2 g) as starting compound and 3,4-dichlorobenzaldehyde (0.99 g) were reacted and treated in the same manner as in Example 121 to give 2.7 g of 4-amino-5-chloro-N-((1-(3-(3,4-dichlorobenzylamino)propyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 121

Sources & evidence

ORD record
ord-a6b94105655b43199452e8fd2f6a06b4
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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