Formaldehyde → HCID 54300182, compound

HRID 344409Notes

Reaction equation

HRID 344409 reaction equation
[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]N)[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1.[CH2:27]=O.[C:29]([BH3-])#[N:30].[Na+]>>[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:30]([CH3:29])[CH3:27])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 540083634-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 54300182HCID 54300182, compound

Procedure

4-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (1.0 g) as starting compound, 37% formalin (0.45 ml) and sodium cyanoborohydride (0.34 g) were reacted and treated in the same manner as in Example 136 to give 0.48 g of 4-amino-5-chloro-N-((1-(5-dimethylaminopentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 136

Sources & evidence

ORD record
ord-0cb59ebf421d412a8c37615f0ca66380
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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