Cyclohexanone → HCID 54070614, compound

HRID 344410Notes

Reaction equation

HRID 344410 reaction equation
[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH2:21])[CH2:12][CH2:11]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1.[C:27]1(=O)[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1.C([BH3-])#N.[Na+]>>[NH2:1][C:2]1[C:23]([Cl:24])=[CH:22][C:5]([C:6]([NH:8][CH2:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][NH:21][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:14][CH2:15]2)=[O:7])=[C:4]([O:25][CH3:26])[CH:3]=1

Participants

4

Reactant 3

HCID 7967CyclohexanoneHCID 5003444Sodium cyanoborohydrideHCID 540083634-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide

Product 1

HCID 54070614HCID 54070614, compound

Procedure

4-Amino-N-(1-(5-aminopentyl)piperidin-4-ylmethyl)-5-chloro-2-methoxybenzamide (2.0 g) as starting compound, cyclohexanone (0.73 ml) and sodium cyanoborohydride (0.86 g) were reacted and treated in the same manner as in Example 136 to give 1.42 g of 4-amino-5-chloro-N-((1-(5-(cyclohexylamino)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 136

Sources & evidence

ORD record
ord-c27206460f1744a180ee4ce247949412
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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