Potassium Carbonate → HCID 70075065, compound

HRID 344468Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([C:37]1[C:38]2[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=2[S:40][CH:41]=1)=[O:36]>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([C:37]3[C:38]4[CH:45]=[CH:44][CH:43]=[CH:42][C:39]=4[S:40][CH:41]=3)=[O:36])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

HCID 70075488HCID 70075488, compound

Product 1

HCID 70075065HCID 70075065, compoundYield 44.9%

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (0.50 g) as starting compound, potassium carbonate (0.75 g) and 6-bromo-1-(3-benzo[b]thienyl)-1-hexanone (0.42 g) were reacted and treated in the same manner as in Example 172 to give 0.32 g of 4-amino-5-chloro-N-((1-(6-(3-benzo[b]thienyl)-6-oxohexyl)piperidin-4-yl)-methyl)-2-methoxybenzamide.

Workup

customwere reacted
additiontreated in the same manner as in Example 172

Sources & evidence

ORD record: ord-613e7d1259ee43b2bda7e1359afaaeb1
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05864039

Reaction notes

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