Potassium Carbonate → HCID 70074136, compound

HRID 344473Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[C:29]1([S:35]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]Cl)(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[ClH:20].[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][S:35]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)(=[O:36])=[O:37])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 43168508HCID 43168508, compound

HCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 70074136HCID 70074136, compoundYield 48.2%

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (0.48 g) as starting compound, potassium carbonate (0.80 g) and 5-phenylsulfonylpentyl chloride (0.40 g) were reacted and treated in the same manner as in Example 199 to give 0.17 g of 4-amino-5-chloro-2-methoxy-N-((1-(5-phenylsulfonylpentyl)piperidin-4-yl)methyl)-benzamide hydrochloride.

Workup

customwere reacted
additiontreated in the same manner as in Example 199

Sources & evidence

ORD record: ord-bdb5dd828d45408db0ae8ed61ab4e23b
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05864039

Reaction notes

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