Potassium Carbonate → HCID 54488041, compound

HRID 344504Notes

Reaction equation

Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:29][C:30]1[CH:43]=[CH:42][C:33]([CH2:34][O:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]Cl)=[CH:32][CH:31]=1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][O:35][CH2:34][C:33]3[CH:32]=[CH:31][C:30]([Cl:29])=[CH:43][CH:42]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 13654376HCID 13654376, compound

HCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 54488041HCID 54488041, compoundYield 94.8%

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (1.0 g) as starting compound, potassium carbonate (1.5 g) and 5-(4-chlorobenzyloxy)pentyl chloride (1.5 g) were reacted and treated in the same manner as in Example 168 to give 1.3 g of 4-amino-5-chloro-N-((1-(5-(4-chlorobenzyloxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

customwere reacted
additiontreated in the same manner as in Example 168

Sources & evidence

ORD record: ord-ad276a0ad573484f826e6b3adc0daaa1
Source dataset: uspto-grants-1999_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05864039

Reaction notes

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