5-((1,4-Benzodioxan-6-yl)methoxy)pentyl chloride → 4-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide

HRID 344530Notes

Reaction equation

HRID 344530 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[O:23]1[C:28]2[CH:29]=[CH:30][C:31]([CH2:33][O:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]Cl)=[CH:32][C:27]=2[O:26][CH2:25][CH2:24]1>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:39][CH2:38][CH2:37][CH2:36][CH2:35][O:34][CH2:33][C:31]3[CH:30]=[CH:29][C:28]4[O:23][CH2:24][CH2:25][O:26][C:27]=4[CH:32]=3)[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

3

Reactant 2

HCID 538386235-((1,4-Benzodioxan-6-yl)methoxy)pentyl chlorideHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 537981464-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 5-((1,4-benzodioxan-6-yl)methoxy)pentyl chloride were reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 168

Sources & evidence

ORD record
ord-a9c23064af2145c5a7ee1c296cd56e6e
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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