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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 344530Generated: October 28, 2026

5-((1,4-Benzodioxan-6-yl)methoxy)pentyl chloride → 4-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide

https://huagongshe.com/reaction/344530

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-((1,4-Benzodioxan-6-yl)methoxy)pentyl chlorideHCID 53838623—
Reactant4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochlorideHCID 69966330—
Product4-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamideHCID 53798146—

Reaction Steps

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride as starting compound and 5-((1,4-benzodioxan-6-yl)methoxy)pentyl chloride were reacted and treated in the same manner as in Example 168 to give 4-amino-5-chloro-N-((1-(5-((1,4-benzodioxan-6-yl)methoxy)pentyl)piperidin-4-yl)methyl)-2-methoxybenzamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05864039
Source datasetuspto-grants-1999_01
ORD IDord-a9c23064af2145c5a7ee1c296cd56e6e
Source noteuspto-grants-1999_01