HCID 54247374, compound → HCID 54190377, compound

HRID 344532Notes

Reaction equation

HRID 344532 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[N:34]([CH3:41])[CH:33]=1)=[O:31]>>[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([C:32]3[C:40]4[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=4)[N:34]([CH3:41])[CH:33]=3)=[O:31])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

3

Reactant 2

HCID 54247374HCID 54247374, compoundHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 54190377HCID 54190377, compound

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (0.98 g) as starting compound and 7-bromo-1-(1-methyl-1 H-indol-3-yl)-1-heptanone were reacted and treated in the same manner as in Example 172 to give 0.83 g of 4-amino-5-chloro-2-methoxy-N-((1-(7-(1-methyl-1 H-indol-3-yl)-7-oxoheptyl)piperidin-4-yl)methyl)-benzamide. This compound was treated with hydrochloric acid-ethanol to obtain its hydrochloride as crystals.

Workup

  1. customwere reacted
  2. additiontreated in the same manner as in Example 172

Sources & evidence

ORD record
ord-78afa29a4f7e456b84f347dae6026c90
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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