[(4-Chlorobutane-1-sulfonyl)methyl]benzene → HCID 70076541, compound

HRID 344536Notes

Reaction equation

HRID 344536 reaction equation
Cl.Cl.[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1.[CH2:23]([S:30]([CH2:33][CH2:34][CH2:35][CH2:36]Cl)(=[O:32])=[O:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[ClH:20].[NH2:3][C:4]1[C:19]([Cl:20])=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH:12]2[CH2:13][CH2:14][N:15]([CH2:36][CH2:35][CH2:34][CH2:33][S:30]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:31])=[O:32])[CH2:16][CH2:17]2)=[O:9])=[C:6]([O:21][CH3:22])[CH:5]=1

Participants

3

Reactant 2

HCID 284426[(4-Chlorobutane-1-sulfonyl)methyl]benzeneHCID 699663304-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride

Product 1

HCID 70076541HCID 70076541, compoundYield 65.4%

Procedure

4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride (2 g) and 4-(benzylsulfonyl)butyl chloride (1.46 g) were reacted and treated in the same manner as in Example 199 to give 0.96 g of 4-amino-N-((1-(4-(benzylsulfonyl)butyl)piperidin-4-yl)-methyl)-5-chloro-2-methoxybenzamide hydrochloride.

Workup

  1. additiontreated in the same manner as in Example 199

Sources & evidence

ORD record
ord-ed16b25ad5bb435ba8bc084aae3d0640
Source dataset
uspto-grants-1999_01
Patent number
US05864039

Reaction notes

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