HRID34454

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12221

1-Propyne, 3-chloro-

C3H3Cl

HCID12849769

5-[(2,4-Diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenol

C13H16N4O3

PRODUCTS

生成物

HCID12849803

5-[[3,4-Dimethoxy-5-(2-propyn-1-yloxy)phenyl]methyl]-2,4-pyrimidinediamine

C16H18N4O3

PROCEDURE

实验过程

The title compound was prepared from 2,4-diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine and propargyl chloride by the procedure of Example 1A. Recrystallization from 95% ethanol gave off-white needles (73%); mp 160°-161°. Anal. Calcd for C16H18N4O3 : C, 61.13; H, 5.77; N, 17.82. Found: C, 60.96; H, 5.80; N, 17.75.

WORKUP

后处理

customRecrystallization from 95% ethanol