Hydrochloric Acid → 4-amino-5-chloro-2-methoxy-N-((1-(3-oxo-3-phenylpropyl)piperidin-4-yl)methyl)benzamide hydrochloride

HRID 344544ノート

反応式

HRID 344544 の反応式
Cl.[NH2:2][C:3]1[C:31]([Cl:32])=[CH:30][C:6]([C:7]([NH:9][CH2:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]3(OCC[O:26]3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:13][CH2:12]2)=[O:8])=[C:5]([O:33][CH3:34])[CH:4]=1>CO>[ClH:32].[NH2:2][C:3]1[C:31]([Cl:32])=[CH:30][C:6]([C:7]([NH:9][CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:16]2)=[O:8])=[C:5]([O:33][CH3:34])[CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 545659284-amino-5-chloro-N-((1-(3,3-ethylenedioxy-3-phenylpropyl)piperidin-4-yl)methyl)-2-methoxybenzamide

生成物 1

HCID 700765574-amino-5-chloro-2-methoxy-N-((1-(3-oxo-3-phenylpropyl)piperidin-4-yl)methyl)benzamide hydrochloride収率 154.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Methanol (40 ml) and 1N hydrochloric acid (100 ml) were added to 4-amino-5-chloro-N-((1-(3,3-ethylenedioxy-3-phenylpropyl)piperidin-4-yl)methyl)-2-methoxybenzamide (8.8 g), and the mixture was stirred at refluxing temperature for 1.5 hr. The reaction mixture was further stirred under ice-cooling for 1 hr, and the precipitated crystals were collected by filtration to give 6.7 g of 4-amino-5-chloro-2-methoxy-N-((1-(3-oxo-3-phenylpropyl)piperidin-4-yl)methyl)benzamide hydrochloride.

後処理

  1. temperatureat refluxing temperature for 1.5 hr
  2. stirringThe reaction mixture was further stirred under ice-
  3. temperaturecooling for 1 hr
  4. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-6740dd178ab34174a8ff479f8c6548dc
出典データセット
uspto-grants-1999_01
特許番号
US05864039

反応ノート

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