Methyl iodide → HCID 67925092, compound

HRID 344686Notes

Reaction equation

HRID 344686 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[O:5][CH:6]=1.[CH3:13][I:14]>C(O)C>[I-:14].[CH3:13][N+:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:4]2[O:5][CH:6]=[C:2]([CH3:1])[N:3]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13812588HCID 13812588, compound

Product 1

HCID 67925092HCID 67925092, compoundYield 83.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.8 g of 3-(4-methyloxazol-2-yl)-pyridine and 19.4 g of methyl iodide are mixed together in 140 cm3 of ethanol, then heated under reflux for 6 hours. The solvent is evaporated, the residue is crystallized from a mixture of ethanol and ether and 17 g of expected product is obtained, which is recrystallized from ethanol.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 6 hours
  3. customThe solvent is evaporated
  4. customthe residue is crystallized from a mixture of ethanol and ether

Sources & evidence

ORD record
ord-a39e6049d82d47178f3e6a2f5588b23f
Source dataset
uspto-grants-1991_10
Patent number
US05053416

Reaction notes

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