Methyl iodide → 1-Methyl-3-(5-methyloxazol-2-yl)-pyridinium iodide

HRID 344693Notes

Reaction equation

HRID 344693 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[I:13][CH3:14]>C(O)C>[I-:13].[CH3:14][N+:9]1[CH:10]=[CH:11][CH:12]=[C:7]([C:5]2[O:6][C:2]([CH3:1])=[CH:3][N:4]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 196125075-Methyl-2-(3-pyridyl)-oxazole

Product 1

HCID 679250801-Methyl-3-(5-methyloxazol-2-yl)-pyridinium iodide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g of 3-(5-methyloxazol-2-yl)-pyridine prepared as indicated in Chimica Therap 4, 437 (1973) is dissolved in 50 cm3 of ethanol, 3 cm3 of iodomethane is added and the whole is heated under reflux for 10 hours. After cooling and decanting, ether is added, and after filtering, 8.68 g of product is obtained. M.p.=147°-148° C., after crystallization from ethanol.

Workup

  1. temperaturethe whole is heated
  2. temperatureunder reflux for 10 hours
  3. temperatureAfter cooling
  4. customdecanting
  5. additionether is added
  6. filtrationafter filtering

Sources & evidence

ORD record
ord-51fd0243d6b04062a1810d51847ac00e
Source dataset
uspto-grants-1991_10
Patent number
US05053416

Reaction notes

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