反应详情

温度

0 °C

5.0 g (4.34 mmols) of 2,3,4-trimethoxybenzyl alcohol was dropwise added to 10 ml of conc. hydrochloric acid under stirring at 0° C. The mixture was stirred at 0° C. for further 5 minutes. After the reaction, water was added to the mixture followed by extraction of the solution with diethyl ether. The diethyl ether layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to afford 4.80 g of 2,3,4-trimethoxybenzyl chloride as a crude product.

1. stirringThe mixture was stirred at 0° C. for further 5 minutes
2. additionwas added to the mixture
3. extractionfollowed by extraction of the solution with diethyl ether
4. dry with materialThe diethyl ether layer was dried over anhydrous sodium sulfate
5. customthe solvent was evaporated under reduced pressure