Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

Participants

Reaction Steps

2-amino-6,7-dimethoxy tetraline (0.4 g; 2.07 mmoles) was dissolved in 20 ml CH2Cl2. Dicyclohexylcarbodiimide (0.4 g; 2.07 mmoles) and carbotertbutoxyglycine (0.36 g; 2.07 mmoles) were added to the solution. The solution was kept under stirring for 2 hours. Dicyclohexylurea that formed was then filtered off. The filtrate was extracted with a saturated solution of NaHCO3, diluted HCl and H2O till neutrality was reached. The organic phase separated and dried was concentrated under vacuum. The residue thus obtained was chromatographed on a silica gel column, eluting with CHCl3 --AcOEt, 1:1.

Provenance & Evidence