Ethanolamine → 138148-37-5

HRID 344761Notes

Reaction equation

HRID 344761 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].C[O:6][C:7](=O)[CH2:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>>[C:11]([NH:10][CH2:9][CH2:8][C:7]([NH:4][CH2:3][CH2:1][OH:2])=[O:6])(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 12859671Methyl N-acetyl-beta-alaninate

Product 1

HCID 19805630138148-37-5Yield 62.6%

Conditions

Temperature
85 °C

Procedure

A mixture of 0.42 g of ethanolamine and 1.0 g of N-acetyl-β-alanine methyl ester was heated at 85° C. for 4 hours. The resulting yellow oil solidified upon cooling and was crystallized from acetonitrile, giving 0.75 g of the desired compound as a white solid, mp 122-125° C.

Workup

  1. temperatureupon cooling
  2. customwas crystallized from acetonitrile

Sources & evidence

ORD record
ord-d65c514e95c846b281f498b931691aab
Source dataset
uspto-grants-1991_10
Patent number
US05053426

Reaction notes

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