反应详情

A mixture of 4-chloro-6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran(3g) and sodium azide (0.9g) in N,N-dimethylformamide (20 ml) was stirred for 3 days at room temperature. Water was added and the mixture extracted with ethyl acetate, the organic phase was separated and further washed with water, then dried over anhydrous sodium sulphate. Filtration and evaporation of the solvent in vacuo gave the title compound (3.03g) as a solid, which was used in the next step without further purification.

1. extractionthe mixture extracted with ethyl acetate
2. customthe organic phase was separated
3. washfurther washed with water
4. dry with materialdried over anhydrous sodium sulphate
5. filtrationFiltration and evaporation of the solvent in vacuo