Propionyl chloride → 1-Propanone, 1-(5-chloro-6-methoxy-2-naphthalenyl)-

HRID 344822Notes

Reaction equation

HRID 344822 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH3:13].[C:14](Cl)(=[O:17])[CH2:15][CH3:16].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[Cl:1][C:2]1[C:3]([O:12][CH3:13])=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[CH:9][C:8]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:7]2

Participants

5

Reactant 3

HCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 115646231-Chloro-2-methoxynaphthalene

Product 1

HCID 108006011-Propanone, 1-(5-chloro-6-methoxy-2-naphthalenyl)-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

reacting under Friedel-Crafts conditions 1-chloro-2-methoxy-naphthalene with propionyl chloride in methylene chloride at a temperature of from about 0° C. to ambient temperature in the presence of aluminum chloride to form 1-(5-chloro-6-methoxy-2-naphthyl)-1-propanone,

Sources & evidence

ORD record
ord-29c31bcb48824620869b75a57bd27925
Source dataset
uspto-grants-1991_10
Patent number
US05053533

Reaction notes

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