HCID 11197026, compound → HCID 54191058, compound

HRID 344865Notes

Reaction equation

HRID 344865 reaction equation
[F:1][C:2]1[C:20](F)=[CH:19][C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1.[CH3:22][O:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]2[CH2:36][NH:35][CH2:34][CH2:33][NH:32]2)=[CH:27][CH:26]=1>>[F:1][C:2]1[C:20]([N:35]2[CH2:34][CH2:33][NH:32][CH:31]([C:28]3[CH:27]=[CH:26][C:25]([CH2:24][O:23][CH3:22])=[CH:30][CH:29]=3)[CH2:36]2)=[CH:19][C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 11197026HCID 11197026, compoundHCID 540464682-[4-(Methoxymethyl)phenyl]piperazine

Product 1

HCID 54191058HCID 54191058, compoundYield 89.3%

Procedure

Using the procedure described in Example 16, but starting with 7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid (1.16 g) and (RS)-2-[4-(methoxymethyl)phenyl]piperazine (1.82 g), (RS)-7-fluoro-8-{3-[4-(methoxymethyl)phenyl]-1-piperazinyl}-1-methyl-4-oxo -1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.70 g) is obtained in the form of a yellow solid, decomposing at 284° C.

Sources & evidence

ORD record
ord-b86395b919da434ba7c47c0d2402b55a
Source dataset
uspto-grants-1991_10
Patent number
US05053509

Reaction notes

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