7,8-Difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid → HCID 54191058, compound

Participants

Reaction Steps

Using the procedure described in Example 16, but starting with 7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid (1.16 g) and (RS)-2-[4-(methoxymethyl)phenyl]piperazine (1.82 g), (RS)-7-fluoro-8-{3-[4-(methoxymethyl)phenyl]-1-piperazinyl}-1-methyl-4-oxo -1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.70 g) is obtained in the form of a yellow solid, decomposing at 284° C.

Provenance & Evidence