HCID 11197026, compound → HCID 53783365, compound

HRID 344867Notes

Reaction equation

HRID 344867 reaction equation
F[C:2]1[C:20](F)=[CH:19][C:5]2=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=[C:4]2[CH:3]=1.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[CH2:34][NH:33][CH2:32][CH2:31][NH:30]2)=[CH:25][C:24]=1[O:35][CH3:36]>>[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([CH:29]2[NH:30][CH2:31][CH2:32][N:33]([C:20]3[CH:2]=[CH:3][C:4]4[C:5]([CH:19]=3)=[N:6][C:7]3[N:8]([CH3:18])[CH:9]=[C:10]([C:15]([OH:17])=[O:16])[C:11](=[O:14])[C:12]=3[CH:13]=4)[CH2:34]2)=[CH:25][C:24]=1[O:35][CH3:36]

Participants

3

Reactant 2

HCID 11197026HCID 11197026, compoundHCID 541580682-Methoxy-4-(2-piperazinyl)benzenamine

Product 1

HCID 53783365HCID 53783365, compoundYield 76.2%

Procedure

Working under the conditions of Example 16, but starting with 7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid (1.16 g) and (RS)-2-(4-amino-3-methoxyphenyl)piperazine (1.82 g), (RS)-8-[3-(4-amino-3-methoxyphenyl)-1-piperazinyl]-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.40 g) is obtained in the form of a yellow solid, decomposing at 259° C.

Sources & evidence

ORD record
ord-61e0ff0f31c24d68808f4d4bb64721b7
Source dataset
uspto-grants-1991_10
Patent number
US05053509

Reaction notes

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