HuagongsheHuagongshe Chemistry Print Report · For research reference only
7,8-Difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid → HCID 53783365, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7,8-Difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid | HCID 11197026 | — |
| Reactant | 2-Methoxy-4-(2-piperazinyl)benzenamine | HCID 54158068 | — |
| Product | HCID 53783365 | HCID 53783365 | 76.2% |
Reaction Steps
Working under the conditions of Example 16, but starting with 7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid (1.16 g) and (RS)-2-(4-amino-3-methoxyphenyl)piperazine (1.82 g), (RS)-8-[3-(4-amino-3-methoxyphenyl)-1-piperazinyl]-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]-naphthyridine-3-carboxylic acid (1.40 g) is obtained in the form of a yellow solid, decomposing at 259° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-61e0ff0f31c24d68808f4d4bb64721b7 |
| Source note | uspto-grants-1991_10 |