HCID 1514412, compound → HCID 53735830, compound

HRID 344878Notes

Reaction equation

HRID 344878 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:9]=[C:10]3[CH:20]=[C:19]([F:21])[C:18](F)=[CH:17][C:11]3=[N:12][C:13]=2[N:14]([CH3:16])[CH:15]=1)=[O:5])[CH3:2].[C:24]1([C@H:30]2[CH2:35][NH:34][CH2:33][CH2:32][NH:31]2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:23])[C:8]2[CH:9]=[C:10]3[CH:20]=[C:19]([F:21])[C:18]([N:34]4[CH2:33][CH2:32][NH:31][C@@H:30]([C:24]5[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=5)[CH2:35]4)=[CH:17][C:11]3=[N:12][C:13]=2[N:14]([CH3:16])[CH:15]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 1514412HCID 1514412, compoundHCID 98399873-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 53735830HCID 53735830, compoundYield 73.4%

Procedure

Working under the conditions of Example 25, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (0.8 g) and (S)-2-phenylpiperazine (0.5 g), (S)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (0.85 g) is obtained in the form of a yellow solid, mp. 226° C.

Sources & evidence

ORD record
ord-e6bc3339053c4ac9b00f15caa93b624f
Source dataset
uspto-grants-1991_10
Patent number
US05053509

Reaction notes

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