HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 1514412, compound → HCID 53735830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 1514412 | HCID 1514412 | — |
| Reactant | 3-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine | HCID 9839987 | — |
| Product | HCID 53735830 | HCID 53735830 | 73.4% |
Reaction Steps
Working under the conditions of Example 25, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (0.8 g) and (S)-2-phenylpiperazine (0.5 g), (S)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (0.85 g) is obtained in the form of a yellow solid, mp. 226° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-e6bc3339053c4ac9b00f15caa93b624f |
| Source note | uspto-grants-1991_10 |