反应详情

Working under the conditions of Example 20, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (51.6 g) and (R)-2-phenylpiperazine (31.7 g), (R)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (66.86 g) is obtained in the form of a yellow solid, m.p. 221° C.