HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 1514413, compound → HCID 53735831, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 1514413 | HCID 1514413 | — |
| Reactant | 3-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine | HCID 9839987 | — |
| Product | HCID 53735831 | HCID 53735831 | 89.6% |
Reaction Steps
Working under the conditions of Example 20, but starting with 3-ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine (51.6 g) and (R)-2-phenylpiperazine (31.7 g), (R)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine (66.86 g) is obtained in the form of a yellow solid, m.p. 221° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05053509 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-ccc958cb8182409787ddd3ac227de6a9 |
| Source note | uspto-grants-1991_10 |