Diethyl Ether → 7-(4'-Fluorophenyl)-6-hydroxymethyl-2-methyl-5-(1'-methylethyl)pyrazolo [1,5-a]pyrimidin

HRID 345021Notes

Reaction equation

HRID 345021 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]3[N:14]=[C:15]([CH3:17])[CH:16]=[C:12]3[N:11]=[C:10]([CH:18]([CH3:20])[CH3:19])[C:9]=2[C:21](OCC)=[O:22])=[CH:4][CH:3]=1.[H-].C([Al+]CC(C)C)C(C)C.C1(C)C=CC=CC=1.[Cl-].[NH4+].C(OCC)C>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]3[N:14]=[C:15]([CH3:17])[CH:16]=[C:12]3[N:11]=[C:10]([CH:18]([CH3:20])[CH3:19])[C:9]=2[CH2:21][OH:22])=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 25517Ammonium ChlorideHCID 14994686Ethyl 7-(4'-fluorophenyl)-2-methyl-5-(1'-methylethyl)pyrazolo[1,5-a]pyrimidin-6-ylcarboxylate2×HCID 86583787Diisobutylaluminumhydride toluene

Product 1

HCID 149946877-(4'-Fluorophenyl)-6-hydroxymethyl-2-methyl-5-(1'-methylethyl)pyrazolo [1,5-a]pyrimidinYield 84%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

4.40 g (12.9 mmol) of ethyl 7-(4'-fluorophenyl)-2-methyl-5-(1'-methylethyl)pyrazolo[1,5-a]pyrimidin-6-ylcarboxylate was dissolved in 40 ml of dry toluene under a nitrogen atmosphere and cooled to 0° C. in an ice bath. To this solution, 33 ml of a 16 weight % diisobutylaluminium hydride-toluene solution was dropwise added, and then, the mixture was stirred at 0° C. for one hour. After confirming the complete disappearance of ethyl 7-(4'-fluorophenyl)-2-methyl-5-(1'-methylethyl)pyrazolo[1,5-a]pyrimidin-6-ylcarboxylate by thin layer chromatography, a saturated ammonium chloride aqueous solution was added thereto at 0° C. to terminate the reaction. Diethyl ether was added to the reaction mixture, and the organic layer was separated. The gelled substance was dissolved by an addition of a sodium hydroxide aqueous solution and newly extracted with ethyl ether. The ethyl ether extracts were put together and dried over anhydrous magnesium sulfate. The extract was subjected to filtration, and the solvent was distilled off and the residue was recrystallized from ethyl acetate to obtain 3.24 g (yield: 84%) of the slightly yellow desired compound.

Workup

  1. customat 0° C. to terminate
  2. customthe reaction
  3. customthe organic layer was separated
  4. dissolutionThe gelled substance was dissolved by an addition of a sodium hydroxide aqueous solution
  5. extractionnewly extracted with ethyl ether
  6. dry with materialdried over anhydrous magnesium sulfate
  7. filtrationThe extract was subjected to filtration
  8. distillationthe solvent was distilled off
  9. customthe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-29218921d3d343ce84d3e435fff34257
Source dataset
uspto-grants-1991_10
Patent number
US05055472

Reaction notes

Loading…