Hydrochloric Acid → 1H-Tetrazole-1-acetic acid, 5-phenyl-

HRID 345100Notes

Reaction equation

HRID 345100 reaction equation
[C:1]1([C:7]2[N:11]([CH2:12][C:13]([O:15]C)=[O:14])[N:10]=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)(=O)C>[C:1]1([C:7]2[N:11]([CH2:12][C:13]([OH:15])=[O:14])[N:10]=[N:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15007244HCID 15007244, compound

Product 1

HCID 6745071H-Tetrazole-1-acetic acid, 5-phenyl-Yield 69.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 100 mg of methyl 5phenyl-1-tetrazoleacetate, 0.6 ml of acetic acid and 1 ml of a 4N-hydrochloric acid was stirred at 80°to 90° C. for 2 hours. The reaction solution was evaporated under reduced pressure. The precipitated solid was filtered, washed with cold water and recrystallized from 50% ethanol-water, to give 64.1 mg (yield: 69.2%) of 5-phenyltetrazole-1-acetic acid.

Workup

  1. customThe reaction solution was evaporated under reduced pressure
  2. filtrationThe precipitated solid was filtered
  3. washwashed with cold water
  4. customrecrystallized from 50% ethanol-water

Sources & evidence

ORD record
ord-110788017f0c4fa185ae0e20b6132f5d
Source dataset
uspto-grants-1991_10
Patent number
US05055481

Reaction notes

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