反应详情

A mixture of (RS)-3-carboethoxy-4-(2-chloro-1,1,2-trifluoroethoxy)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole 5 (0.95 g), aqueous sodium hydroxide solution (2M; 20 ml) and methanol (20 ml) was stirred at room temperature for 20 hours. The solution was acidified with hydrochloric acid (2M), diluted with water (50 ml) and extracted with ether (2×30 ml). The combined extracts were dried over magnesium sulfate and evaporated to give (RS)-3-carboxy-4-(2-chloro-1,1,2-trifluoroethoxy)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.7 g) as a yellow solid, m.p. 149°-159° C.

1. extractionextracted with ether (2×30 ml)
2. dry with materialThe combined extracts were dried over magnesium sulfate
3. customevaporated