Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloropropionyl chloride | HCID 69364 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro- | HCID 74615 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (3-Chloropropanoyl)urea | HCID 12937417 | 79.8% |
Reaction Steps
20.0 g of N,N'-trimethyleneurea are partially dissolved in 1000 ml of toluene under reflux and admixed with 20.2 g of triethylamine and then dropwise, in the course of 90 minutes, with a solution of 25.4 g of 3-chloropropionyl chloride. Subsequent stirring for 30 minutes, cooling down to 5° C., removal of undissolved matter by filtration and evaporating the filtrate in vacuo gives 24 g of chloropropionylurea of the formula ##STR70## as a beige powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05055567 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-e25446250eeb40bdb22986ef2666127e |
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| Source note | uspto-grants-1991_10 |
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