反应详情

0.670 g (1.675 mmol) of 1-[(1,4-dihydro-5-hydroxy-4-oxo-2-pyridyl)carbonyl]-2-[2-methyl-2-(phthalimidooxy)propionyl]hydrazine was dissolved in 1.5 ml of dimethylformamide and treated with 0.077 g (1.675 mmol) of methylhydrazine. After stirring for 21/2 hours at room temperature about 2 ml of ethanol were added. The crystals obtained were filtered off and discarded. The filtrate was evaporated under strongly reduced pressure and the product was crystallized from ethanol. 1-[2-(aminooxy)-2-methylpropionyl]-2-[(1,4-dihydro-5-hydroxy-4-oxo-2-pyridyl)carbonyl]hydrazine was obtained as white crystals melting at 234° (dec.).

1. additionwere added
2. customThe crystals obtained
3. filtrationwere filtered off
4. customThe filtrate was evaporated under strongly reduced pressure
5. customthe product was crystallized from ethanol