Formaldehyde → 5-(2-Piperidinomethylpropionyl)-3-phenylisoxazole

Participants

Reaction Steps

Added to 10 ml of ethyl alcohol were 2.0 g (10.0 mmol) of 5-propionyl-3-phenylisoxazole and 1.7 g (20.0 mmol) of piperidine, followed by the dropwise addition of 1.63 ml (20.0 mmol) of a 37% aqueous solution of formaldehyde under ice cooling. After the reaction mixture was stirred for 2 hours at room temperature, the solvent was distilled off under reduced pressure. The residue was dissolved in ethyl ether. The organic layer was washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, whereby the target compound, namely, 5-(2-piperidinomethylpropionyl)-3-phenylisoxazole was obtained as crystals.

Provenance & Evidence