Water → HCID 13051147, compound

HRID 345241Notes

Reaction equation

HRID 345241 reaction equation
[O:1]=[C:2]1[N:9]2[CH:4]([CH2:5][CH2:6][O:7]C2(C)C)[CH:3]1[CH:12]([CH3:14])[CH3:13].O>C(O)(=O)C>[CH:12]([CH:3]1[CH:4]([CH2:5][CH2:6][OH:7])[NH:9][C:2]1=[O:1])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 962WaterHCID 130511448-Oxo-2,2-dimethyl-7alpha-isopropyl-3-oxa-1-azabicyclo[4.2.0]octane

Product 1

HCID 13051147HCID 13051147, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
65 °C

Procedure

8-oxo- 2,2-dimethyl-7α-isopropyl-3-oxa-1-azabicyclo[4.2.0]octane 1.0 g is dissolved in 8 ml of acetic acid and 2 ml H2O is added. The mixture is heated at 65° C. for 1.25 hrs. The acetic acid and H2O are removed under reduced pressure and the residue is taken up in C6H6 and evaporated to give 3-isopropyl-4-(2-hydroxyethyl)azetidinone.

Workup

  1. customThe acetic acid and H2O are removed under reduced pressure
  2. customevaporated

Sources & evidence

ORD record
ord-80d5fcd7df9d43f78bf664def874a077
Source dataset
uspto-grants-1991_10
Patent number
US05055573

Reaction notes

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