HCID 11132825, compound → {[(1,3-Thiazol-2-yl)amino]methylene}bis(phosphonic acid)

Participants

Reaction Steps

6.57 g (17 mmol) of 1-(thiazol-2-ylamino)-methane-1,1-diphosphonic acid tetraethyl ester are dissolved in 70 ml of N hydrochloric acid and heated under reflux for 6 hours. In the course of the reaction, the product separates out in the form of a fine white precipitate. After cooling to room temperature, filtration is carried out and the product is washed with aqueous methanol. 4.33 g (93% of the theoretical yield) of 1-(thiazol-2-ylamino)methane-1,1-diphosphonic acid of m.p. 275° (decomposition) are obtained.

Provenance & Evidence